Olsson L, Mathé G
Biomedicine. 1979 Dec;30(6):281-2.
Cytotoxic autoreactive lymphoid cells have been demonstrated to be a normal immunologic component in both normal and tumor-bearing organisms. The cells have a high antineoplastic potential. They are cytotoxic in vitro to non-immunogenic tumor cells, and a high in vivo activity of such cells may be positively correlated to in vivo regression of tumors. It is suggested that the cytotoxic activity of cytotoxic autoreactive cells reflects a natural mechanism to removal of all types of aberrant cells of which malignant cells are only a subset. It is further deduced that such mechanisms must be independent of cell surface neoantigens, and that cytotoxic autoreactive mechanisms with high probability therefore also are efficient against spontaneous malignant tumors.
细胞毒性自身反应性淋巴细胞已被证明是正常生物和荷瘤生物体内的一种正常免疫成分。这些细胞具有很高的抗肿瘤潜力。它们在体外对非免疫原性肿瘤细胞具有细胞毒性，并且此类细胞在体内的高活性可能与肿瘤在体内的消退呈正相关。有人提出，细胞毒性自身反应性细胞的细胞毒性活性反映了一种清除所有类型异常细胞的天然机制，而恶性细胞只是其中的一个子集。进一步推断，这种机制必须独立于细胞表面新抗原，因此具有高概率的细胞毒性自身反应性机制也能有效对抗自发性恶性肿瘤。
