Cortisol secretion following nomifensine administration in normal subjects.

The effects of the oral administration of nomifensine, which inhibits endogenous cathecolamine re-uptake, on secretion of prolactin and cortisol were investigated in 12 normal subjects. In all the volunteers, a significant decrease of prolactin levels was observed following nomifensine administration. Cortisol levels were unaffected by this pharmacological treatment. The role of hypothalamic dopaminergic inhibitory system on ACTH-cortisol axis is discussed.