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跨膜稳态运输模型中的协同效应。I.

Cooperative effects in models of steady-state transport across membranes. I.

作者信息

Hill T L, Chen Y

出版信息

Proc Natl Acad Sci U S A. 1970 Apr;65(4):1069-76. doi: 10.1073/pnas.65.4.1069.

Abstract

Three simple models are discussed which show cooperative effects in the steady-state transport of neutral molecules across a membrane. The Bragg-Williams approximation is employed, and its limitations discussed. In this approximation to cooperative problems, the diagram method for the calculation of steady-state probabilities and fluxes can still be used. This paper is closely related to one by Blumenthal, Changeux, and Lefever, and provides the foundation for sequels on an oscillatory steady-state phase-transition model (part II) and on simple models possibly related to steady-state potassium ion transport across a nerve membrane (part III).

摘要

讨论了三种简单模型,它们显示了中性分子跨膜稳态运输中的协同效应。采用了布拉格 - 威廉姆斯近似,并讨论了其局限性。在这种协同问题的近似方法中,仍可使用计算稳态概率和通量的图解法。本文与布卢门撒尔、尚热和勒费弗的一篇论文密切相关,并为关于振荡稳态相变模型(第二部分)以及可能与钾离子跨神经膜稳态运输相关的简单模型(第三部分)的后续研究奠定了基础。

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