Gordon A S, Zanjani E D, Levere R D, Kappas A
Proc Natl Acad Sci U S A. 1970 Apr;65(4):919-24. doi: 10.1073/pnas.65.4.919.
The effects of a number of steroid compounds on erythropoiesis in normal and polycythemic mice were examined. Of the steroids that stimulated erythropoiesis, the hormone testosterone and certain 5beta-H C(19) and C(21) nonhormonal metabolites were the most effective. Anti-erythropoietin abolished the erythropoiesis-stimulating effects of testosterone but not those exerted by the 5beta-H steroid, 11-ketopregnanolone. Similarly, testosterone but not 11-ketopregnanolone evoked the production of erythropoiesis-stimulating factor in rats. It is concluded that two mechanisms underlie the stimulating actions of steroids on erythropoiesis; one through the production of erythropoietin and the second involving a more direct influence on the blood-forming tissues. The 5beta-H steroid metabolites are postulated to act on erythropoiesis via the latter mechanism.
研究了多种甾体化合物对正常和红细胞增多症小鼠红细胞生成的影响。在刺激红细胞生成的甾体中，激素睾酮以及某些5β-H C(19)和C(21)非激素代谢产物最为有效。抗促红细胞生成素消除了睾酮对红细胞生成的刺激作用，但对5β-H甾体11-酮孕烷醇酮的刺激作用无效。同样，睾酮而非11-酮孕烷醇酮能诱导大鼠产生促红细胞生成刺激因子。得出结论，甾体对红细胞生成的刺激作用有两种机制；一种是通过促红细胞生成素的产生，另一种是对造血组织有更直接的影响。推测5β-H甾体代谢产物通过后一种机制作用于红细胞生成。
