UK2054对流感病毒增殖的影响。

The effects of UK2054 on the multiplication of influenza viruses.

作者信息

Barry R D, Davies P

出版信息

J Hyg (Lond). 1970 Mar;68(1):151-8. doi: 10.1017/s0022172400028606.

DOI:10.1017/s0022172400028606

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2130783/

Abstract

The isoquinoline compound UK2054 prevents the uptake of influenza virus by susceptible cells. Pre-incubation of virus particles with 500 mug./ml. UK2054 at 37 degrees C. for 2 hr. does not reduce virus infectivity. Host cells vary in their responsiveness to the inhibitory effect of UK2054; virus multiplication is inhibited in chick allantoic cells by lower concentrations than those required to inhibit virus growth in chick embryo fibroblasts. The effectiveness of UK2054 is reduced by the presence of serum.It is concluded that inhibition of influenza virus multiplication by UK2054 might result from interaction of the inhibitor with both virus and cells. Any direct combination between inhibitor and virus is completely reversible.

摘要

异喹啉化合物UK2054可阻止流感病毒被易感细胞摄取。将病毒颗粒与500微克/毫升的UK2054在37摄氏度下预孵育2小时，并不会降低病毒的感染性。宿主细胞对UK2054的抑制作用的反应性各不相同；与抑制鸡胚成纤维细胞中病毒生长所需的浓度相比，较低浓度的UK2054即可抑制鸡尿囊细胞中的病毒增殖。血清的存在会降低UK2054的有效性。得出的结论是，UK2054对流感病毒增殖的抑制可能是由于该抑制剂与病毒和细胞均发生了相互作用。抑制剂与病毒之间的任何直接结合都是完全可逆的。

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