从电组织中分离出一种胆碱能蛋白脂质受体。
Isolation of a cholinergic proteolipid receptor from electric tissue.
作者信息
La Torre J L, Lunt G S, De Robertis E
出版信息
Proc Natl Acad Sci U S A. 1970 Mar;65(3):716-20. doi: 10.1073/pnas.65.3.716.
Abstract
A proteolipid protein having a high affinity for methyl (14)C-hexamethonium, (3)H-p-(trimethylammonium)-benzene diazonium fluoroborate, and (acetyl-1-(14)C)choline chloride was isolated and purified from the electric tissue of Torpedo marmorata and Electrophorus electricus. At variance with the "receptor proteolipid" from the brain the one from electric tissue apparently does not bind atropine sulfate.
摘要
从斑纹电鳐和电鳗的电组织中分离并纯化出一种对甲基（14）C - 六甲铵、（3）H - 对 - （三甲基铵） - 苯重氮氟硼酸盐和（乙酰 - 1 - （14）C）氯化胆碱具有高亲和力的蛋白脂质。与来自大脑的“受体蛋白脂质”不同，来自电组织的这种蛋白脂质显然不结合硫酸阿托品。
相似文献
1
Isolation of a cholinergic proteolipid receptor from electric tissue.从电组织中分离出一种胆碱能蛋白脂质受体。
Proc Natl Acad Sci U S A. 1970 Mar;65(3):716-20. doi: 10.1073/pnas.65.3.716.
2
Conductance properties of artificial lipidic membranes containing a proteolipid from Electrophorus. Response to cholinergic agents.含电鳗蛋白脂质的人工脂质膜的电导特性。对胆碱能药物的反应。
J Gen Physiol. 1972 Oct;60(4):454-70. doi: 10.1085/jgp.60.4.454.
3
Binding of -bungarotoxin to the cholinergic receptor proteolipid from electrophorus electroplax.银环蛇毒素与电鳗电板胆碱能受体蛋白脂质的结合。
Biochim Biophys Acta. 1972 Jul 3;274(1):258-65. doi: 10.1016/0005-2736(72)90299-4.
4
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.眼镜蛇（3H）α-毒素与电鳗和电鳐电器官膜片段的结合。II. 胆碱能激动剂和拮抗剂对氚化α-神经毒素结合的影响。
Mol Pharmacol. 1974 Jan;10(1):15-34.
5
The use of a cholinergic fluorescent probe for the study of the receptor proteolipid.使用胆碱能荧光探针研究受体蛋白脂质。
Mol Pharmacol. 1971 Sep;7(5):530-7.
6
Blocking by -bungarotoxin of the high affinity binding site of the cholinergic receptor proteolipid from Electrophorus.用银环蛇毒素阻断电鳐胆碱能受体蛋白脂质的高亲和力结合位点。
Eur J Pharmacol. 1972 Feb;17(2):303-5. doi: 10.1016/0014-2999(72)90176-8.
7
Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue.用去污剂从电鳐电组织中提取的胆碱能受体蛋白的分子量和四级结构。
FEBS Lett. 1973 Dec 15;38(1):11-5. doi: 10.1016/0014-5793(73)80500-9.
8
9
Isolation of the cholinergic receptor protein of Torpedo electric tissue.电鳐电组织胆碱能受体蛋白的分离
Adv Biochem Psychopharmacol. 1972;6:111-34.
10
Cholinergic receptors in Electrophorus.电鳗中的胆碱能受体。
Neurosci Res Program Bull. 1973 Jun;11(3):246-52.
引用本文的文献
1
Fine structure of ultrathin artificial membranes : I. Changes by acetylcholine addition in lipid proteolipid membranes.超薄人工膜的精细结构：I. 乙酰胆碱添加对脂质-蛋白脂膜的影响。
J Membr Biol. 1971 Dec;6(4):353-67. doi: 10.1007/BF02116579.
2
Use of a snake venom toxin to characterize the cholinergic receptor protein.使用蛇毒毒素来表征胆碱能受体蛋白。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1241-7. doi: 10.1073/pnas.67.3.1241.
3
Proteolipid metabolism in denervated muscle.失神经肌肉中的蛋白脂质代谢
Biochem J. 1971 Jan;121(1):23P-24P. doi: 10.1042/bj1210023pb.
4
Reactivity to acetylcholine developed by artificial lipid membranes containing a proteolipid from Electrophorus electricus.由含有电鳗蛋白脂质的人工脂质膜产生的对乙酰胆碱的反应性。
Experientia. 1973 Nov 15;29(11):1451-2. doi: 10.1007/BF01922872.
5
Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates).来自龙虾轴突膜的能结合胆碱能配体和局部麻醉剂的大分子（受体 - 普鲁卡因 - 乙酰胆碱 - 尼古丁 - 钠和钾通道）。
Proc Natl Acad Sci U S A. 1972 Jan;69(1):177-81. doi: 10.1073/pnas.69.1.177.
6
Conductance properties of artificial lipidic membranes containing a proteolipid from Electrophorus. Response to cholinergic agents.含电鳗蛋白脂质的人工脂质膜的电导特性。对胆碱能药物的反应。
J Gen Physiol. 1972 Oct;60(4):454-70. doi: 10.1085/jgp.60.4.454.
本文引用的文献
1
Affinity labeling-a general method for labeling the active sites of antibody and enzyme molecules.亲和标记——一种标记抗体和酶分子活性位点的通用方法。
Biochemistry. 1962 Nov;1:1031-9. doi: 10.1021/bi00912a013.
2
Cholinergic binding capacity of proteolipids from isolated nerve-ending membranes.
Science. 1967 Nov 17;158(3803):928-9. doi: 10.1126/science.158.3803.928.
3
Fine structural localization of acetylcholinesterase in electroplaque of the electric eel.乙酰胆碱酯酶在电鳗电板中的精细结构定位
J Cell Biol. 1966 Jun;29(3):475-95. doi: 10.1083/jcb.29.3.475.
4
Fractionation of lipids and proteolipids from cat grey white matter by chromatography on an organophilic dextran gel.
J Chromatogr. 1969 May 20;41(3):400-9. doi: 10.1016/0021-9673(64)80154-0.
5
Action of Triton X-100 on lipids and proteolipids of nerve-ending membranes.曲拉通X-100对神经末梢膜脂质和蛋白脂质的作用。
Life Sci II. 1968 Feb 15;7(4):203-8. doi: 10.1016/0024-3205(68)90307-x.
6
Subcellular distribution and possible nature of the alpha-adrenergic receptor in the CNS.中枢神经系统中α-肾上腺素能受体的亚细胞分布及可能性质
Life Sci. 1968 Oct 1;7(19):1093-103. doi: 10.1016/0024-3205(68)90215-4.
7
Affinity labeling of the acetylcholine-receptor.乙酰胆碱受体的亲和标记
Proc Natl Acad Sci U S A. 1967 Nov;58(5):2063-70. doi: 10.1073/pnas.58.5.2063.
8
Approaches to the molecular nature of pharmacological receptors.药理学受体分子本质的研究方法。
Pharmacol Rev. 1969 Jun;21(2):131-81.
9
Isolation and chemical nature of the receptor for d-tubocurarine in nerve-ending membranes of the cerebral cortex.
J Neurobiol. 1969;1(1):41-52. doi: 10.1002/neu.480010105.
10
Curare and acetylcholine receptor substance.箭毒与乙酰胆碱受体物质
Nature. 1968 Apr 27;218(5139):330-3. doi: 10.1038/218330a0.
Zotero 插件