Wulff V J, Fahy J L
Brain Res Bull. 1979 Nov-Dec;4(6):803-7. doi: 10.1016/0361-9230(79)90016-9.
Chlorobutanol (1,1,1-trichlor-2-methyl-2-propanol) decreases the duration of the latent period of Limulus ventral eye receptor potentials. This effect is both concentration and intensity dependent. Between 0.05 and 1 mM chlorobutanol in sea water the extent of latency shortening effect of chlorobutanol linear function of the logarithm of the chlorobutanol concentration. The latency shortening effect of chlorobutanol diminishes with decreasing intensity of stimulation and virtually disappears at intensities just exceeding threshold. These results are explained by postulating that the latent period is composed of two processes only one of which is sensitive to chlorobutanol and, further, that the duration of the chlorobutanol-sensitive process is not appreciably affected by the stimulating intensity. This model of a two component latent period may be tested experimentally. In several experiments prolonged exposure of ventral photoreceptor cells to chlorobutanol coupled with a short exposure to calcium deficient sea water produced a collapse of the receptor potential followed by a slow recovery after returning to perfusion with normal sea water. During the recovery a slow, low amplitude positive wave exists which has been tentatively called a prepotential.
氯丁醇（1,1,1 - 三氯 - 2 - 甲基 - 2 - 丙醇）可缩短鲎腹眼感受器电位的潜伏期。这种效应既取决于浓度，也取决于强度。在海水中氯丁醇浓度为0.05至1 mM之间时，氯丁醇缩短潜伏期的效应程度是氯丁醇浓度对数的线性函数。氯丁醇缩短潜伏期的效应随刺激强度降低而减弱，在强度刚超过阈值时实际上就消失了。这些结果可通过假设潜伏期由两个过程组成来解释，其中只有一个过程对氯丁醇敏感，而且，对氯丁醇敏感的过程的持续时间不受刺激强度的明显影响。这种双组分潜伏期模型可以通过实验进行检验。在几个实验中，将腹侧感光细胞长时间暴露于氯丁醇，再短时间暴露于缺钙海水，会导致感受器电位崩溃，然后在恢复用正常海水灌注后缓慢恢复。在恢复过程中存在一个缓慢的、低幅度的正波，暂时称为预电位。
