每周给药的安圭定I期研究。
Phase I study of anguidine administered weekly.
作者信息
Belt R J, Haas C D, Joseph U, Goodwin W, Moore D, Hoogstraten B
出版信息
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1993-5.
PMID:526932
Abstract
Anguidine was administered on a weekly schedule to 20 patients. Gastrointestinal and neurologic toxic effects were dose-limiting for both 4- and 8-hour infusions of anguidine. Myelosuppression was infrequent and not dose-related. Recommended starting doses for weekly anguidine are 6.0 mg/m2 for patients with normal hepatic function and 3.5 mg/m2 for patients with liver dysfunction.
摘要
按每周一次的给药方案，对20名患者施用安圭丁。对于安圭丁4小时和8小时输注，胃肠道和神经毒性作用均为剂量限制性。骨髓抑制不常见且与剂量无关。安圭丁每周给药的推荐起始剂量，肝功能正常的患者为6.0mg/m²，肝功能不全的患者为3.5mg/m²。
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