Vogel C L, Love N H, East D R, Moore M R, Smalley R V
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2077-9.
Nineteen females with metastatic breast cancer (73% with visceral disease) treated with cyclophosphamide, Adriamycin, and 5-fluorouracil (CAF) cytoreduction followed by, and then alternated with, an intensive "cycle-active" regimen were evaluable. Sixteen of the 19 (84%) patients responded to CAF prior to initiation of the cycle-active regimen, and median remission duration for CAF responders was 50 weeks. The regimen was tolerable and the remission rates and durations were at least as good as those seen with CAF alone. This regimen is now being compared with CAF in a randomized trial of the Southeastern Cancer Study Group.
19例转移性乳腺癌女性患者（73%有内脏疾病）接受了环磷酰胺、阿霉素和5-氟尿嘧啶（CAF）进行细胞减灭治疗，随后采用强化“周期活性”方案并与之交替，这些患者可进行评估。19例患者中有16例（84%）在开始周期活性方案之前对CAF有反应，CAF反应者的中位缓解持续时间为50周。该方案耐受性良好，缓解率和缓解持续时间至少与单独使用CAF时所见相当。目前，在东南部癌症研究组的一项随机试验中，正在将该方案与CAF进行比较。
