Tanaka T, Craig A W, Lajtha L G
Br J Cancer. 1970 Mar;24(1):138-48. doi: 10.1038/bjc.1970.17.
A kinetic study was made on murine myeloid leukaemia, using the myeloid leukaemia colony in the spleen as a model system. The number of myeloid leukaemia colony-forming units (MLCFU) recoverable from the bone marrow, spleen and liver increased exponentially as a function of time from day 1 up to day 9, after the initial lag period of 12-24 hours. The f-values were estimated to be about 67 per cent in the above 3 organs. After day 10, the number of MLCFU declined in these organs. The myeloid leukaemia was sensitive to cyclophosphamide and chlorambucil, as determined by the slopes of the survival curves obtained for MLCFU. Finally, an entity of the mixed type in the myeloid leukaemia colony was described.
以脾脏中的髓性白血病集落作为模型系统，对小鼠髓性白血病进行了动力学研究。在最初12 - 24小时的延迟期后，从骨髓、脾脏和肝脏中可回收的髓性白血病集落形成单位（MLCFU）的数量从第1天到第9天随时间呈指数增加。上述3个器官中的f值估计约为67%。第10天后，这些器官中MLCFU的数量下降。根据MLCFU获得的存活曲线斜率确定，髓性白血病对环磷酰胺和苯丁酸氮芥敏感。最后，描述了髓性白血病集落中的一种混合型实体。
