用抗肿瘤药物治疗后白血病细胞在体内的免疫改变。
Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug.
作者信息
Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A
出版信息
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1089-95. doi: 10.1073/pnas.66.4.1089.
Abstract
L1210 leukemia was transplanted serially in CDF(1) mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DIC, NSC 45388). After four different lines (C lines) had been treated for several generations, a marked increase in survival time of untreated mice was observed. In contrast, mice treated with DIC or immunosuppressed with cyclophosphamide succumbed earlier with generalized leukemia. Furthermore, a C line showed unusually high sensitivity to chemotherapeutic treatment with 1,3 bis(2-chloroethyl)-1-nitrosourea. The data suggest that C lines acquired strong antigenicity for CDF(1) and DBA/2 hosts. DIC treatment may have selected highly antigenic variants or induced somatic mutations resulting in the appearance of strong new transplantation antigen(s).
摘要
将L1210白血病细胞连续移植到用5 -（3,3 - 二甲基 - 1 - 三氮烯基）咪唑 - 4 - 甲酰胺（DIC，NSC 45388）处理的CDF(1)小鼠体内。在对四个不同品系（C品系）进行了几代处理后，观察到未处理小鼠的存活时间显著增加。相比之下，用DIC处理或用环磷酰胺免疫抑制的小鼠因全身性白血病而更早死亡。此外，一个C品系对1,3 - 双（2 - 氯乙基）- 1 - 亚硝基脲的化疗治疗表现出异常高的敏感性。数据表明，C品系对CDF(1)和DBA/2宿主获得了强抗原性。DIC处理可能选择了高抗原性变体或诱导了体细胞突变，导致出现强的新移植抗原。
相似文献
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Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug.用抗肿瘤药物治疗后白血病细胞在体内的免疫改变。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1089-95. doi: 10.1073/pnas.66.4.1089.
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Effectiveness of antileukemic agents in mice inoculated with leukemia L1210 variants resistant to 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) or 5-(3,3-bis(2-chloroethyl)-1-triazeno)imidazole-4-carboxamide (NSC-82196).抗白血病药物对接种了对5-（3,3-二甲基-1-三氮烯基）咪唑-4-甲酰胺（NSC-45388）或5-（3,3-双（2-氯乙基）-1-三氮烯基）咪唑-4-甲酰胺（NSC-82196）耐药的白血病L1210变体的小鼠的有效性。
Cancer Chemother Rep. 1971 Feb;55(1):9-28.
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5-Fluorouracil (5-Fu; NSC-19893), 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388), vincristine (NSC-67574), and 1,3-bis(2-chloroethyl)-2-nitrosourea (BCNU; NSC-409962) given concomitantly in the treatment of solid tumors in man.5-氟尿嘧啶（5-Fu；NSC-19893）、5-（3,3-二甲基-1-三氮烯基）咪唑-4-甲酰胺（NSC-45388）、长春新碱（NSC-67574）和1,3-双（2-氯乙基）-2-亚硝基脲（卡莫司汀；NSC-409962）联合用于治疗人类实体瘤。
Cancer Chemother Rep. 1972 Feb;56(1):107-47.
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Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and cyclophosphamide (NSC-26271) on nicotinamide adenine dinucleotide glycohydrolase in normal and leukemic mouse tissues.1,3-双（2-氯乙基）-1-亚硝基脲（NSC-409962）和环磷酰胺（NSC-26271）对正常及白血病小鼠组织中烟酰胺腺嘌呤二核苷酸糖水解酶的影响
Cancer Chemother Rep. 1968 Sep;52(5):569-78.
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