抗体形成组织的核酸改变。
Altered nucleic acids of antibody-forming tissues.
作者信息
Little J R, Donahue H A
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1299-306. doi: 10.1073/pnas.67.3.1299.
Abstract
RNA.DNA hybridization experiments suggest differences between the DNA from the liver and spleen of the same animal (rabbit) and between the RNAs from lymph nodes stimulated by different antigens. A larger proportion of spleen DNA than of liver DNA was complementary to the RNA isolated from antigen-stimulated lymph nodes. No difference between liver and spleen DNA was observed in hybrids formed with RNA from lymph nodes of nonimmune animals. This suggests the presence of unique or redundant genes coding for immunoglobulin polypeptide chains in antibody-forming cells.
摘要
RNA-DNA杂交实验表明，同一动物（兔子）肝脏和脾脏的DNA之间以及不同抗原刺激的淋巴结RNA之间存在差异。与从抗原刺激的淋巴结中分离出的RNA互补的脾脏DNA比例大于肝脏DNA。在用非免疫动物淋巴结的RNA形成的杂交体中，未观察到肝脏和脾脏DNA之间的差异。这表明在抗体形成细胞中存在编码免疫球蛋白多肽链的独特或冗余基因。
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