Hasselgren P O, Almersjö O, Gustavsson B, Seeman T
Eur Surg Res. 1979;11(4):267-76. doi: 10.1159/000128074.
Liver protein synthesis was studied with an in vitro method during and after 1 h of hemorrhagic shock in the dog. Protein synthesis was significantly decreased already 15 min after induction of hypovolemia and was about 50% of the initial value at the end of the shock period. 2 h following retransfusion, protein synthesis was normalized. Some of the underlying mechanisms leading to decreased protein synthesis in hemorrhagic shock are discussed. Serum concentrations of liver enzymes were unchanged during the shock period indicating that the liver metabolism may be affected without changes in parameters often used to evaluated liver function.
采用体外方法研究了犬失血性休克1小时期间及之后肝脏蛋白质的合成情况。在血容量减少诱发后仅15分钟，蛋白质合成即显著下降，在休克期末约为初始值的50%。再输血2小时后，蛋白质合成恢复正常。文中讨论了导致失血性休克时蛋白质合成减少的一些潜在机制。休克期间肝脏酶的血清浓度未发生变化，这表明肝脏代谢可能受到影响，而常用于评估肝功能的参数却未改变。
