大鼠感染路氏锥虫：腺嘌呤的作用
Trypanosoma lewisi infection in the rat: effect of adenine.
作者信息
Taliaferro W H, D'Alesandro P A
出版信息
Proc Natl Acad Sci U S A. 1971 Jan;68(1):1-5. doi: 10.1073/pnas.68.1.1.
Abstract
The reproductive activity of Trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. The drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infection. Peak parasitemia was also enhanced. In terms of host immunity, daily sublethal doses of adenine given to rats within two days before or after infection with T. lewisi significantly depressed a hitherto unrevealed natural immunity to reproduction of the trypanosomes, but only slightly modified the development of acquired immunity.
摘要
当给大鼠注射亚致死剂量的腺嘌呤时，鲁氏锥虫的繁殖活性显著增强，有时可延长2天。从感染前1天或2天开始至感染后2天，在饮食中添加该药物5天或7天和/或腹腔注射时，该药物有效。最高血虫数也有所增加。就宿主免疫力而言，在感染鲁氏锥虫之前或之后两天内给大鼠每日注射亚致死剂量的腺嘌呤，可显著抑制此前未被发现的针对锥虫繁殖的天然免疫力，但对获得性免疫力的发展仅有轻微影响。
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2
Adenine intoxication in relation to in vivo formation and deposition of 2,8-dioxyadenine in renal tubules.腺嘌呤中毒与肾小管中2,8 - 二氧腺嘌呤的体内形成和沉积的关系。
J Pharmacol Exp Ther. 1952 Jan;104(1):20-30.
3
The effect of X irradiation on immunity of the mouse to Trypanosoma duttoni.X射线对小鼠抵抗杜氏锥虫免疫力的影响。
J Infect Dis. 1955 May-Jun;96(3):242-9. doi: 10.1093/infdis/96.3.242.
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Exp Parasitol. 1965 Apr;16:174-81. doi: 10.1016/0014-4894(65)90041-x.
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Exp Parasitol. 1964 Oct;15:430-8. doi: 10.1016/0014-4894(64)90037-2.
6
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J Protozool. 1962 Aug;9:351-8. doi: 10.1111/j.1550-7408.1962.tb02633.x.
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