Burke D H, Brooks J C, Ryan R P, Treml S B
Eur J Pharmacol. 1979 Dec 7;60(2-3):241-3. doi: 10.1016/0014-2999(79)90224-3.
Serotonin levels were measured in the brains of mice at 2 h and 10 days following the administration of a single dose of 10 mg/kg, i.p. of p-chloroamphetamine HCl (PCA). A 44% reduction in the concentration of brain serotonin was noted 2 h after PCA injection. No significant change in brain serotonin was observed 10 days following PCA administration. The time course of the body temperature response to cobaltous chloride (25 mg/kg, i.p.) was recorded 60 min following pretreatment with PCA (10 mg/kg, i.p.). PCA reduced the hypothermic response by approximately 60%, presumably through the depletion of central 5-hydroxytryptamine.
在小鼠腹腔注射单剂量10mg/kg盐酸对氯苯丙胺（PCA）后2小时和10天，测量其大脑中的血清素水平。注射PCA后2小时，大脑血清素浓度降低了44%。PCA给药10天后，大脑血清素未观察到显著变化。在PCA（10mg/kg，腹腔注射）预处理60分钟后，记录对氯化钴（25mg/kg，腹腔注射）的体温反应的时间进程。PCA使体温过低反应降低了约60%，可能是通过消耗中枢5-羟色胺实现的。
