Jacobson M
Proc Natl Acad Sci U S A. 1971 Mar;68(3):528-32. doi: 10.1073/pnas.68.3.528.
Action potentials evoked in the tectum by visual stimulation of the ipsilateral eye were absent in frog larvae and developed during metamorphosis. Formation of the connections underlying these responses is not based on the animal's visual experience. The development of the ipsilateral retinotectal projection occurred normally in frogs reared through metamorphosis in the dark from midlarval stages to adults. Inversion of one eye of frog larvae did not affect the development of ipsilateral retinotectal projections, which developed according to the inherent correspondences between the retinae regardless of the disparities produced by changing the relative positions of the eyes. No compensatory changes occurred in the retinotectal projections in response to the surgical derangement. Skin grafts completely occluding one eye, which were made at early larval stages and left in place for up to 88 days, did not affect the development of normal ipsilateral retinotectal connections. However, abnormal ipsilateral tectal responses evoked by stimulation through either the normal eye or the occluded eye were found in adult frogs after occlusion of one eye from larval stages for more than 121 days. It was concluded that visual stimulation is not required for the normal development of ipsilateral retinotectal connections but is required for their long-term maintenance.
同侧眼视觉刺激诱发的顶盖动作电位在蛙幼体中不存在，而是在变态发育过程中形成。这些反应背后的连接形成并非基于动物的视觉经验。在从幼虫中期到成虫阶段一直处于黑暗中变态发育的青蛙中，同侧视网膜顶盖投射的发育正常。对蛙幼体的一只眼睛进行反转，并不影响同侧视网膜顶盖投射的发育，其发育遵循视网膜之间固有的对应关系，而不考虑因改变眼睛相对位置而产生的差异。视网膜顶盖投射不会因手术紊乱而发生代偿性变化。在幼虫早期进行的完全遮盖一只眼睛的皮肤移植，并保持88天，并不影响正常同侧视网膜顶盖连接的发育。然而，在幼虫阶段一只眼睛被遮盖超过121天的成年青蛙中，发现通过正常眼或被遮盖眼进行刺激会诱发异常的同侧顶盖反应。得出的结论是，同侧视网膜顶盖连接的正常发育不需要视觉刺激，但长期维持则需要视觉刺激。
