海胆卵受精后蛋白质合成激活的机制。
The mechanism of protein synthesis activation after fertilization of sea urchin eggs.
作者信息
Metafora S, Felicetti L, Gambino R
出版信息
Proc Natl Acad Sci U S A. 1971 Mar;68(3):600-4. doi: 10.1073/pnas.68.3.600.
Abstract
Upon fertilization of Paracentrotus lividus eggs, the ability of their ribosomes to form a ternary complex with poly(U) and phenylalanyl-tRNA is enhanced. In addition, it is possible to extract from ribosomes of the unfertilized egg a protein factor that inhibits polyphenylalanine synthesis by decreasing the binding of mRNA and aminoacyl-tRNA to the ribosomes. The observed increase in the rate of protein synthesis that occurs at fertilization could be accounted for by the removal of this inhibitory protein from the ribosomes.
摘要
在海胆卵受精后，其核糖体与聚（U）和苯丙氨酰 - tRNA形成三元复合物的能力增强。此外，从未受精卵的核糖体中可以提取出一种蛋白质因子，该因子通过减少mRNA和氨酰 - tRNA与核糖体的结合来抑制多聚苯丙氨酸的合成。受精时观察到的蛋白质合成速率增加可能是由于核糖体中这种抑制性蛋白质的去除所致。
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