Gloor M, Sprenger H J, Priebe L
Dermatol Monatsschr. 1979 Sep;165(9):665-9.
In 20 healthy male test subjects, a non-specific ointment base was applied to the back of the hand over 16 hours. Two days later, the same ointment base with 0.25% triamcinolone acetonide was once more applied to the back of the hand over 16 hours. The light reflection of the skin was measured by reflection photometry and the heat transport coefficient was measured fluvographically under the condition of the tourniquet test. The results show that the vasoconstrictor effect of triamcinolone acetonide is best detected by the reflection photometric measurements. In fluvographic measurement, the heat transport coefficient is most affected in maximal reactive hyperemia when the tourniquet has been removed. Application of the base led to a reduction of the blood flow and the water content of the skin after 16 hours, whereas the water content of the skin was unaffected in the presence of triamcinolone acetonide.
在20名健康男性受试对象中，将一种非特异性软膏基质涂于手背16小时。两天后，再次将含有0.25%曲安奈德的相同软膏基质涂于手背16小时。通过反射光度法测量皮肤的光反射，并在止血带试验条件下通过荧光成像法测量热传递系数。结果表明，通过反射光度测量能最好地检测到曲安奈德的血管收缩作用。在荧光成像测量中，去除止血带后，最大反应性充血时热传递系数受影响最大。涂抹基质16小时后导致皮肤血流量和含水量降低，而在有曲安奈德存在的情况下皮肤含水量未受影响。
