Hall-Craggs M, Turner M C, Goldblatt P J
Hum Pathol. 1979 Sep;10(5):606-10. doi: 10.1016/s0046-8177(79)80103-3.
A case consistent with recurrent acute poststreptococcal glomerulonephritis but with atypical features is described. Light microscopy revealed a diffuse proliferative glomerulonephritis. A spectrum of ultrastructural features, from the typical "humpy bumpy" subepithelial deposits to the apparent disappearance of the deposits within the epithelial cells, is presented. An unusual piling up of basement membrane material around the deposits is described, together with some areas showing an appearance reminiscent of membranous glomerulopathy. Resorption of the dense deposits within epithelial cells is suggested and a hypothesis advanced that the basement membrane reaction may indicate an incipient chronic immune complex lesion.
本文描述了一例符合复发性急性链球菌感染后肾小球肾炎但具有非典型特征的病例。光镜检查显示弥漫性增生性肾小球肾炎。呈现了一系列超微结构特征，从典型的“驼峰状”上皮下沉积物到上皮细胞内沉积物明显消失。描述了沉积物周围基底膜物质的异常堆积，以及一些区域呈现出类似膜性肾小球病的外观。提示上皮细胞内致密沉积物的吸收，并提出一个假说，即基底膜反应可能表明存在早期慢性免疫复合物病变。
