Fayemi A O, Ali M
Hum Pathol. 1979 Nov;10(6):685-93. doi: 10.1016/s0046-8177(79)80112-4.
The intrarenal arterial and arteriolar changes in the kidneys of 80 patients with chronic renal insufficiency maintained on hemodialysis were studied semiquantitatively by light microscopy and histochemistry. Intimal proliferation was common and accounted for thickening of vessel walls and luminal narrowing. Fibrocollagenous and fibroelastotic intimal changes were located predominantly in the interlobular and arcuate arteries, whereas the fibromucinous intimal lesion was found mainly in the interlobar arteries. Thickening of the media was encountered in 25 per cent, and adventitial fibrosis in 20 per cent of the kidneys. Necrotizing arterial of arteriolar lesions were not seen. The significance of these alterations as a possible cause of renal ischemia and their role in the perpetuation of hypertension are discussed.
对80例维持性血液透析的慢性肾功能不全患者的肾脏进行肾内动脉和小动脉变化的半定量研究，采用光学显微镜和组织化学方法。内膜增生常见，导致血管壁增厚和管腔狭窄。纤维胶原性和纤维弹性内膜变化主要位于小叶间动脉和弓状动脉，而纤维黏液性内膜病变主要见于叶间动脉。25%的肾脏出现中膜增厚，20%的肾脏出现外膜纤维化。未发现坏死性动脉或小动脉病变。讨论了这些改变作为肾缺血可能原因的意义及其在高血压持续存在中的作用。
