中性粒细胞的细胞毒素受体：关于F-甲硫氨酰肽和胃蛋白酶抑制剂共用一种共同受体的证据。
Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor.
作者信息
Nelson R D, Ackerman S K, Fiegel V D, Bauman M P, Douglas S D
出版信息
Infect Immun. 1979 Dec;26(3):996-9. doi: 10.1128/iai.26.3.996-999.1979.
Abstract
Pepstatin, a chemotactic microbial pentapeptide, competes with f-Met-Leu-[3H]Phe for binding to human neutrophils. Furthermore, porcine neutrophils, which neither specifically bind nor respond chemotactically to the synthetic f-methionyl peptides, also fail to respond chemotactically to pepstatin. These results suggest that pepstatin shares a receptor on the neutrophil with f-methionyl peptides, despite their completely different amino acid compositions. The specificity of this cytotaxin receptor may therefore be broader than expected and depend on ligand characteristics distinct from primary structure.
摘要
胃蛋白酶抑制剂是一种具有趋化作用的微生物五肽，它能与f-Met-Leu-[3H]Phe竞争结合人中性粒细胞。此外，猪的中性粒细胞既不特异性结合合成的甲硫氨酰肽，也不对其产生趋化反应，对胃蛋白酶抑制剂也无趋化反应。这些结果表明，尽管胃蛋白酶抑制剂和甲硫氨酰肽的氨基酸组成完全不同，但它们在中性粒细胞上共享一个受体。因此，这种细胞趋化因子受体的特异性可能比预期的更广，并且取决于不同于一级结构的配体特征。
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