一种新型半合成头孢菌素（AL - 226）在兔体内的药代动力学研究。

Pharmacokinetic study of a new semisynthetic cephalosporin (AL-226) in rabbits.

作者信息

Dominguez-Gil A A, Cepeda M, Vila J L, Garcia J J

出版信息

J Antibiot (Tokyo). 1979 May;32(5):482-7. doi: 10.7164/antibiotics.32.482.

DOI:10.7164/antibiotics.32.482

Abstract

The pharmacokinetics of AL-226, a new semi-synthetic cephalosporin, were studied after i.v. and i.m. administrations to rabbits at doses of 10, 20, 30 and 40 mg/kg. The average values of the pharmacokinetic parameters after bolus i.v. administration of the antibiotic expressed by an open two-compartment kinetic model were: alpha = 0.131 min.-1, beta = 0.0341 min-1, K12 = 0.0287 min.-1, K21 = 0.0552 min.-1, K13 = 0.081 min.-1 a linear relationship between C0 and dose was found. The urinary excretion constants after i.v. administration were: 0.0266 min.-1, 0.0294 min-1, 0.0289 min.-1, 0.0306 min.-1, for doses of 10, 20, 30 and 40 mg/kg, respectively. The pharmacokinetic parameters after i.v. administration were used to determine the absorption constant: 0.0525 min.-1, 0.057 min.-1, 0.0596 min.-1, 0.0511 min.-1, after i.m. administration for doses of 10, 20, 30 and 40 mg/kg, respectively.

摘要

在以10、20、30和40mg/kg的剂量对家兔进行静脉注射和肌肉注射后，研究了一种新型半合成头孢菌素AL-226的药代动力学。以开放二室动力学模型表示的抗生素静脉推注给药后的药代动力学参数平均值为：α = 0.131分钟-1，β = 0.0341分钟-1，K12 = 0.0287分钟-1，K21 = 0.0552分钟-1，K13 = 0.081分钟-1，发现C0与剂量之间存在线性关系。静脉注射给药后的尿排泄常数分别为：10、20、30和40mg/kg剂量下分别为0.0266分钟-1、0.0294分钟-1、0.0289分钟-1、0.0306分钟-1。静脉注射给药后的药代动力学参数用于确定吸收常数：10、20、30和40mg/kg肌肉注射剂量后分别为0.0525分钟-1、0.057分钟-1、0.0596分钟-1、0.0511分钟-1。