喹唑啉抗叶酸剂作为人白血病细胞二氢叶酸还原酶的抑制剂 - Suppr | 超能文献

Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.

作者信息

Johns D G, Capizzi R L, Nahas A, Cashmore A R, Bertino J R

出版信息

Biochem Pharmacol. 1970 Apr;19(4):1528-33. doi: 10.1016/0006-2952(70)90076-6.

DOI:10.1016/0006-2952(70)90076-6

Abstract

摘要

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Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.喹唑啉抗叶酸剂作为人白血病细胞二氢叶酸还原酶的抑制剂

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2

Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro.二氢叶酸还原酶在体内和体外被抑制剂稳定化。

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Purification of tetrahydrofolate dehydrogenase by affinity chromatography.通过亲和色谱法纯化四氢叶酸脱氢酶。

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Dihydrofolate reductase activity and deoxynucleoside incorporation into DNA of human leukocytes. Relation to methotrexate administration.二氢叶酸还原酶活性及脱氧核苷掺入人白细胞DNA的情况。与甲氨蝶呤给药的关系。

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Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.核黄素-甲氨蝶呤相互作用。L1210小鼠白血病细胞中的光化学反应及转运竞争

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Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.培养耐甲氨蝶呤人急性淋巴细胞白血病细胞系及叶酸拮抗剂的作用

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A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.一种检测人白细胞中二氢叶酸还原酶的直接测定法。

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Folate antagonists covalently linked to carbohydrates: synthesis, properties, and use in the purification of dihydrofolate reductases.与碳水化合物共价连接的叶酸拮抗剂：合成、性质及其在二氢叶酸还原酶纯化中的应用

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Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.在静止期与对数期L1210白血病细胞中，二氢叶酸还原酶活性停止后，四氢叶酸辅因子向二氢叶酸相互转化的速率和程度。

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The basis for the disparate sensitivity of L1210 leukemia and Walker 256 carcinoma to a new triazine folate antagonist.

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