水溶性和水不溶性鬼臼毒素衍生物在小鼠肿瘤中的比较。
Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms.
作者信息
Kreis W, Soricelli A
出版信息
J Cancer Res Clin Oncol. 1979;95(3):233-7. doi: 10.1007/BF00410644.
Abstract
Comparison of a water-soluble (27-487) with a water-insoluble (VP-16-213) podophyllotoxin derivative in seven murine neoplasms revealed slight therapeutic superiortiy of VP-16-213 but also slightly greater toxicity when compared with 27-487. A strikingly good response of the Taper liver tumor to both compounds was observed, providing further incentive to the use of podophyllotoxin derivatives in human hepatomas.
摘要
在七种小鼠肿瘤中对水溶性鬼臼毒素衍生物（27 - 487）和水不溶性鬼臼毒素衍生物（VP - 16 - 213）进行比较，结果显示VP - 16 - 213在治疗上略有优势，但与27 - 487相比毒性也略高。观察到两种化合物对锥形体肝肿瘤均有显著良好反应，这为在人类肝癌中使用鬼臼毒素衍生物提供了进一步的动力。
相似文献
1
Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms.水溶性和水不溶性鬼臼毒素衍生物在小鼠肿瘤中的比较。
J Cancer Res Clin Oncol. 1979;95(3):233-7. doi: 10.1007/BF00410644.
2
Etoposide (VP-16-213).
Cancer Treat Rev. 1979 Jun;6(2):107-24. doi: 10.1016/s0305-7372(79)80045-6.
3
Clinical effectiveness and cost-effectiveness of interventions for the treatment of anogenital warts: systematic review and economic evaluation.治疗肛门生殖器疣干预措施的临床有效性和成本效益：系统评价与经济学评估
Health Technol Assess. 2016 Mar;20(24):v-vi, 1-486. doi: 10.3310/hta20240.
4
Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines.一种可阻断多种癌细胞系代谢活性和增殖的水溶性奎尼尼布前药的特性研究。
Eur J Med Chem. 2025 Oct 15;296:117727. doi: 10.1016/j.ejmech.2025.117727. Epub 2025 May 6.
5
The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation.伊立替康、奥沙利铂和雷替曲塞用于治疗晚期结直肠癌：系统评价与经济学评估
Health Technol Assess. 2008 May;12(15):iii-ix, xi-162. doi: 10.3310/hta12150.
6
Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts.单独及与传统抗癌药物联合使用的9-氯-2-甲基玫瑰树碱醋酸盐对人脑肿瘤异种移植瘤治疗的临床前评估。
J Cancer Res Clin Oncol. 1998 Jan;124(1):19-26. doi: 10.1007/s004320050128.
7
8
Comparison of cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease.纤维素、改性纤维素和合成膜在终末期肾病患者血液透析中的比较。
Cochrane Database Syst Rev. 2001(3):CD003234. doi: 10.1002/14651858.CD003234.
9
Effect of hemostasis modifiers of the activity of VP 16 213 on Lewis lung carcinoma.止血调节剂对VP 16 213活性影响Lewis肺癌的研究
Biomedicine. 1977 Jul;27(5):203-8.
10
Progestin-only contraceptives: effects on weight.仅含孕激素的避孕药：对体重的影响。
Cochrane Database Syst Rev. 2016 Aug 28;2016(8):CD008815. doi: 10.1002/14651858.CD008815.pub4.
本文引用的文献
1
Synthesis and antimitotic activity of glycosidic lignan derivatives related to podophyllotoxin.
J Med Chem. 1971 Oct;14(10):936-40. doi: 10.1021/jm00292a012.
2
Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors.
Eur J Cancer (1965). 1973 Mar;9(3):215-21. doi: 10.1016/s0014-2964(73)80021-0.
3
Delayed toxicity of epipodophyllotoxin derivatives (VM 26 and VP 16-213), due to a local effect.鬼臼毒素衍生物（VM 26和VP 16 - 213）的延迟毒性，由局部效应引起。
Eur J Cancer (1965). 1976 Nov;12(11):925-31. doi: 10.1016/0014-2964(76)90010-4.
4
VM26-induced changes in hepatic intermediary metabolism of mice.VM26 诱导的小鼠肝脏中间代谢变化。
Cancer Res. 1977 Sep;37(9):3287-92.
5
VM 26 and VP 16-213: a comparative analysis.
Cancer. 1977 Jul;40(1):334-42. doi: 10.1002/1097-0142(197707)40:1<334::aid-cncr2820400147>3.0.co;2-x.
6
[Therapeutic results using VP 16-213 alone or in combination with 5-fluorouracil in liver cancer (hepatoma)].
Schweiz Med Wochenschr. 1977 Dec 31;107(52):1960-6.
7
Hepatocellular carcinoma in the Malaysian Orang Asli.马来西亚原住民中的肝细胞癌
Cancer. 1976 May;37(5):2263-6. doi: 10.1002/1097-0142(197605)37:5<2263::aid-cncr2820370516>3.0.co;2-g.
8
A phase II study of adriamycin (NSC 123127) in patients with hepatocellular carcinoma from Zambia and the United States.阿霉素（NSC 123127）用于赞比亚和美国肝细胞癌患者的II期研究。
Cancer. 1977 May;39(5):1923-9. doi: 10.1002/1097-0142(197705)39:5<1923::aid-cncr2820390502>3.0.co;2-2.
Zotero 插件