II型糖原贮积症的研究。可的松衍生物对酸性葡萄糖苷酶的影响。
Studies on type II glycogenosis. Effects of cortisone derivatives on acid -glucosidase.
作者信息
Bourne E J, Clarke K, Pridham J B, Rowe J J
出版信息
Biochem J. 1971 Feb;121(4):663-6. doi: 10.1042/bj1210663.
Abstract
Cortisone causes a marked increase in the activity of liver acid alpha-glucosidase 2h after injection into male Wistar rats. Studies on rat liver tissue slices, isolated lysosomes and cultured skin fibroblasts have demonstrated similar elevations of acid alpha-glucosidase activity after incubation with cortisone. Cortisone-treated human liver tissue, obtained by needle biopsy, also shows an increase in acid alpha-glucosidase activity. Neutral alpha-glucosidase activity was not stimulated by cortisone in vivo or in liver slices.
摘要
将可的松注射到雄性Wistar大鼠体内2小时后，其肝脏酸性α-葡萄糖苷酶的活性显著增加。对大鼠肝组织切片、分离的溶酶体和培养的皮肤成纤维细胞的研究表明，与可的松孵育后，酸性α-葡萄糖苷酶活性也有类似升高。通过针吸活检获得的经可的松处理的人肝组织，其酸性α-葡萄糖苷酶活性也有所增加。可的松在体内或肝切片中均未刺激中性α-葡萄糖苷酶活性。
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