Edelman R, Ascher M S, Oster C N, Ramsburg H H, Cole F E, Eddy G A
J Infect Dis. 1979 Nov;140(5):708-15. doi: 10.1093/infdis/140.5.708.
A new, formalin-inactivated vaccine for Venezuelan equine encephalitis (VEE) virus (C-84), prepared from an attenuated vaccine strain of virus (TC-83), was tested in humans. Only occasional, mild, local and systemic reactions were noted in 28 volunteers; no meaningful changes in clinical laboratory values occurred. The vaccine augmented preexisting titers of serum neutralizing antibody to VEE virus in seropositive recipients of TC-83 vaccine, and it induced high titers of neutralizing antibody in nonimmune subjects after one primary and two booster vaccinations. Circulating antibody persisted for at least 14 months in these persons. The neutralizing antibody produced after one dose of C-84 vaccine in immune subjects and after booster doses in nonimmune subjects had broad cross-reactivity within the VEE virus complex. The C-84 vaccine induced a VEE virus-specific lymphocyte transformation response. The vaccine was safe, and immunologic results showed it to be highly antigenic in healthy immune and nomimmune adults.
一种由减毒疫苗株病毒（TC - 83）制备的新型福尔马林灭活委内瑞拉马脑炎（VEE）病毒疫苗（C - 84）在人体中进行了测试。28名志愿者仅出现偶尔的、轻微的局部和全身反应；临床实验室值未发生有意义的变化。该疫苗在接种TC - 83疫苗的血清阳性受试者中提高了对VEE病毒的血清中和抗体的预先存在滴度，并且在一次初次接种和两次加强接种后，在非免疫受试者中诱导出高滴度的中和抗体。这些人的循环抗体持续至少14个月。一剂C - 84疫苗在免疫受试者中以及加强剂量在非免疫受试者中产生的中和抗体在VEE病毒复合体内具有广泛的交叉反应性。C - 84疫苗诱导了VEE病毒特异性淋巴细胞转化反应。该疫苗是安全的，免疫学结果表明它在健康的免疫和非免疫成年人中具有高度抗原性。
