Haseman J K, Hoel D G
J Environ Pathol Toxicol. 1979 Jul-Aug;2(6):1313-27.
This paper considers certain statistical aspects of the problem of among-strain differences in cancer susceptibilities and how these differences may affect the design of toxicity assays. First, in order to investigate the magnitude of within-study, between-strain differences in tumor induction, the data of Innes et al. (1969) were examined. It was found that although there was a very high overall association between mouse strains with respect to the induction of hepatomas, several compounds showed evidence of strain-to-strain variability. Next, a number of long-term carcinogenicity studies with DDT were considered, and among-strain differences in cancer susceptibility for this compound were noted. Finally, it was shown that if susceptible subgroups do exist and certain simplifying assumptions are made, then in many cases tumor increases can be detected more readily by using several inbred mouse strains for study rather than a single outbread stock.
本文探讨了癌症易感性菌株间差异问题的某些统计学方面，以及这些差异如何影响毒性试验的设计。首先，为了研究研究内部菌株间肿瘤诱导差异的程度，对英尼斯等人（1969年）的数据进行了检查。结果发现，尽管小鼠品系在肝癌诱导方面总体关联性很高，但几种化合物显示出菌株间变异性的证据。接下来，考虑了多项关于滴滴涕的长期致癌性研究，并注意到该化合物在癌症易感性方面的菌株间差异。最后表明，如果确实存在易感亚组并做出某些简化假设，那么在许多情况下，使用多个近交系小鼠品系进行研究比使用单一远交群体更容易检测到肿瘤增加。
