Friedman C D, Harbision R D, Jones M M, Weaver A D, Hurwitz G
J Environ Pathol Toxicol. 1979 Jul-Aug;2(6):1529-37.
The oral and iv acute toxicities of several mercury chelates were determined in mice in a search for relationships bearing on the effectiveness of various chelating agents in therapy. It was found that the toxicity was independent of the stability constant for the mercury chelate when the toxicity was expressed on a molar basis. For the mercury chelates of sulfhydryl containing chelating agents, the oral toxicity was unexpectedly low, presumably due to the poor absortion of these materials from the G.I. tract. The results suggest that the toxicities of mercury complexes are independent of the stability constant of the complex over the range of stability constant from 10(23) on down, provided chelation does not drastically alter the distribution of the complex in the body.
为了探寻各种螯合剂在治疗中的有效性关系，测定了几种汞螯合物对小鼠的经口和静脉急性毒性。结果发现，当以摩尔为基础表示毒性时，毒性与汞螯合物的稳定常数无关。对于含巯基螯合剂的汞螯合物，经口毒性出乎意料地低，推测是由于这些物质从胃肠道的吸收较差。结果表明，在稳定常数从10(23) 及以下的范围内，汞配合物的毒性与配合物的稳定常数无关，前提是螯合作用不会显著改变配合物在体内的分布。
