Jones M M, Basinger M A, Weaver A D, Davis C M, Vaughn W K
Res Commun Chem Pathol Pharmacol. 1980 Feb;27(2):363-72.
A comparison in mice has been made of the effectiveness of five chelating agents used clinically for acute mercuric chloride poisoning, or recommended for such use. The compounds examined were N-Acetyl-D,L-penicillamine (NAPA), D-penicillamine (DPA), 2,3-dimercaptosuccinic acid (DMSA), sodium 2,3-dimercaptopropanesulfonate (DMPS), and 2,3-dimercaptopropanol-1 (BAL). The test of effectiveness was their ability to reduce the mortality of acute mercuric chloride poisoning when administered 20 minutes after the mercury at chelate:mercury mole ratios of 10, 15, 20, and 30. All except BAL were found to be effective at the highest mole ratio tested, but N-Acetyl-D,L-penicillamine and sodium 2,3-dimercaptopropanesulfonate were significantly more effective than DMSA and BAL at mole ratios of 10:1. The relative effectiveness does not correlate with available data on stability constants. The toxicity of BAL itself becomes apparent at mole ratios of 20:1 and above.
对临床上用于急性氯化汞中毒或推荐用于此类中毒的五种螯合剂的有效性在小鼠身上进行了比较。所检测的化合物为N-乙酰-D,L-青霉胺（NAPA）、D-青霉胺（DPA）、2,3-二巯基琥珀酸（DMSA）、2,3-二巯基丙磺酸钠（DMPS）和2,3-二巯基丙醇-1（BAL）。有效性测试是在汞中毒后20分钟以螯合剂与汞的摩尔比为10、15、20和30给药时，它们降低急性氯化汞中毒死亡率的能力。除BAL外，在测试的最高摩尔比下均发现有效，但在摩尔比为10:1时，N-乙酰-D,L-青霉胺和2,3-二巯基丙磺酸钠比DMSA和BAL显著更有效。相对有效性与关于稳定常数的现有数据不相关。BAL本身的毒性在摩尔比为20:1及以上时变得明显。
