Jorgensen P N, Güttler F, Rubin B
Scand J Immunol. 1975;4(4):383-9. doi: 10.1111/j.1365-3083.1975.tb02640.x.
Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elimination of cytotoxicity to specificities determined by one of the H-2 loci after adsorption of the immune lymphoid cells onto fibroblasts bearing this specificity suggest a state of diversity among effector lymphocytes reactive to the antigens determined by either the H-2K or the H-2D locus of the H-2 complex. Thymus cells activated in vivo were less specifically adsorbable than spleen cells of tumor-allografted mice.
对一种H-2基因型产生免疫的脾细胞或胸腺细胞，对第三方基因型的同种异体靶细胞具有细胞毒性，前提是该靶细胞与在体内用于致敏的H-2基因型共享由H-2复合体的H-2K或H-2D位点决定的私有特异性。目前关于免疫淋巴细胞吸附到携带这种特异性的成纤维细胞上后，对由H-2复合体的一个H-2位点决定的特异性的细胞毒性消除的结果表明，对由H-2复合体的H-2K或H-2D位点决定的抗原产生反应的效应淋巴细胞之间存在多样性状态。体内活化的胸腺细胞比肿瘤同种异体移植小鼠的脾细胞更不易被特异性吸附。
