性交后给予神经氨酸酶可完全抑制小鼠怀孕。
Total suppression of pregnancy in mice by post-coital administration of neuraminidase.
作者信息
Gasic G J, Gasic T B
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):793-8. doi: 10.1073/pnas.67.2.793.
Because of certain analogies between the spread of tumors and different steps of pregnancy culminating in egg implantation and invasive growth, pregnant mice were treated at different intervals post coitum with two thrombocytopenic agents which can reduce metastases by interfering with vascular lodgement and growth of tumor cells. It was found that both neuraminidase and antiplatelet serum were active against pregnancy, the enzyme being by far the more effective of the two. The mechanism of this effect involves both egg implantation and egg development. The effect cannot be explained solely by the thrombocytopenia produced by both agents.
由于肿瘤扩散与妊娠的不同阶段（最终以卵子着床和侵入性生长为 culminating）存在某些相似之处，在交配后的不同时间间隔，用两种血小板减少剂对怀孕小鼠进行治疗，这两种药物可通过干扰肿瘤细胞的血管着床和生长来减少转移。结果发现，神经氨酸酶和抗血小板血清对妊娠均有影响，其中神经氨酸酶的效果要比另一种有效得多。这种影响机制涉及卵子着床和卵子发育。这种影响不能仅用两种药物所产生的血小板减少来解释。 （注：原文中“culminating in egg implantation and invasive growth”的“culminating”此处暂无法准确对应，大概意思是与卵子着床和侵入性生长相关的妊娠阶段有相似之处，整体译文尽量保持原意通顺）
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