沙门氏菌O抗原的聚合机制：脂连接中间体的利用
Mechanism of polymerization of the Salmonella O-antigen: utilization of lipid-linked intermediates.
作者信息
Kanegasaki S, Wright A
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):951-8. doi: 10.1073/pnas.67.2.951.
Abstract
Cell envelope fractions from Salmonella can utilize exogenous lipid-linked intermediates for the synthesis of polymeric O-antigen. We describe a method for preparing aqueous suspensions of lipid intermediates and show that freezing and thawing of cell envelope-lipid intermediate mixtures is required for efficient synthesis. The lipid intermediates move freely in the hydrophobic environment of the membrane.
摘要
沙门氏菌的细胞膜组分可利用外源脂质连接中间体来合成聚合O抗原。我们描述了一种制备脂质中间体水悬浮液的方法，并表明细胞膜-脂质中间体混合物的冻融对于高效合成是必需的。脂质中间体在膜的疏水环境中自由移动。
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