小鼠（小家鼠）中的两种辐射诱导染色体倒位。

Two radiation-induced chromosomal inversions in mice (Mus musculus).

作者信息

Roderick T H, Hawes N L

出版信息

Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7. doi: 10.1073/pnas.67.2.961.

DOI:10.1073/pnas.67.2.961

PMID:5289032

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283299/

Abstract

Whole-body x-irradiation of male mice has produced presumptive paracentric inversions in 15 animals, as evidenced by high frequencies of first meiotic anaphase bridges. Two of the highest frequencies observed have been propagated through several generations and found to behave as dominant genes. Acentric fragments were observed associated with about 10% of the bridges. The first inversion, in linkage group XIII, has been designated In(13)1Rk, and the second, in linkage group XVII, In(17)2Rk. For In(13)1Rk, recombination was reduced between loci inside and outside the inverted segment.

摘要

对雄性小鼠进行全身X射线照射后，在15只动物中产生了推定的臂内倒位，第一次减数分裂后期桥的高频率出现证明了这一点。观察到的两个最高频率已通过几代繁殖，并发现其表现为显性基因。观察到约10%的桥伴有无着丝粒片段。第一个倒位发生在连锁群XIII中，已命名为In(13)1Rk，第二个倒位发生在连锁群XVII中，命名为In(17)2Rk。对于In(13)1Rk，倒位片段内外的基因座之间的重组减少。