Hori C G, Warren S, Patterson W B, Chute R N
Am J Pathol. 1971 Nov;65(2):279-92.
Sources of protracted gamma radiation adjacent to bone were found to induceosteogenic sarcoma in half of the exposed males. Osteogenic sarcomas appeared in 3 males remote from the radioactive sources and may not have been radiation induced. Some tumors were small enough so that the site of origin could be determined accurately: some arose from endosteum, others from periosteum. Although portions of the skeleton in the female rats incidentally received doses of over 20,000 rads, no osteogenic sarcomas developed in them. Parauterine sources induced adenocarcinoma of the endometrium in 14 of 32 rats (44%). The incidence of carcinoma of the ovary (12%) was lower than expected. Carcinomas of the breast were frequent, but often distant from the source. Increased total dose, which was usually related to length of time of exposure, produced an increased incidence of cancer and a shortening of the latent period. However, extremely high doses (over a million rads to bone and hundreds of thousands to the uterus) at times failed to induce cancers.
发现邻近骨骼的持续性伽马辐射源可使半数受照射雄性大鼠诱发骨肉瘤。在远离放射源的3只雄性大鼠身上出现了骨肉瘤，可能并非由辐射诱发。一些肿瘤体积小到足以准确确定其起源部位：有些起源于骨内膜，有些起源于骨膜。尽管雌性大鼠的部分骨骼偶然接受了超过20000拉德的剂量，但它们并未发生骨肉瘤。子宫旁源使32只大鼠中的14只（44%）诱发子宫内膜腺癌。卵巢癌的发生率（12%）低于预期。乳腺癌很常见，但往往远离放射源。总剂量增加通常与暴露时间长短有关，会导致癌症发生率增加和潜伏期缩短。然而，极高剂量（骨骼超过100万拉德，子宫超过数十万拉德）有时未能诱发癌症。
