长期给予乙醇对γ-丁内酯诱导的多巴积累增加的抑制作用。
Attenuation of the gamma-butyrolactone-induced increase in DOPA accumulation by chronic ethanol administration.
作者信息
Liljequist S, Engel J
出版信息
J Neural Transm. 1979;46(3):195-204. doi: 10.1007/BF01250785.
PMID:528994
Abstract
The effect of gamma-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors.
摘要
在对大鼠进行乙醇慢性处理后，研究了γ-丁内酯（GBL）对芳香族氨基酸脱羧酶抑制后多巴积累的影响。在乙醇处理的大鼠中，GBL诱导的多巴积累显著减少。随着乙醇处理时间的延长，这种效应在边缘前脑似乎更为明显。提示慢性乙醇处理可能导致中枢GABA受体敏感性降低。
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