Howell J R
J Pharmacokinet Biopharm. 1979 Dec;7(6):675-9. doi: 10.1007/BF01061214.
The examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing intervals.
给出这些例子是为了说明如何使用梅茨勒的非线性回归程序来估计多剂量模型中的参数。其中一个例子的模型是一组涉及指数和的方程，而另一个模型是一组反映一级吸收和米氏排泄的微分方程。在这两种情况下，给药间隔中的一组数据均未给出。
