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Solid-state acetylation of codeine phosphate by aspirin.

作者信息

Galante R N, Visalli A J, Patel D M

出版信息

J Pharm Sci. 1979 Dec;68(12):1494-8. doi: 10.1002/jps.2600681208.

DOI:10.1002/jps.2600681208
PMID:529038
Abstract

A nonsolvolytic (solid-state) acetylation of codeine phosphate in the presence of aspirin to yield acetylcodeine phosphate is reported. GLC assays for the simultaneous determination of aspirin and salicylic acid and codeine and acetylcodeine are described. The apparent heat of activation for codeine phosphate is estimated, and the possible reaction mechanisms are discussed.

摘要

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Solid-state acetylation of codeine phosphate by aspirin.
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