Hillman B J, Herman P G, Baldwin W M
Lymphology. 1979 Dec;12(4):241-6.
Previous studies have shown significant microvascular changes during the evolution of the immune response. In order to assess the BCG-induced microvascular alterations in the lymph node, we injected the left foot pad of 23 rabbits with 1.6 x 10(6) live BCG/kg weight; the right side served as control. Following a period of 1 to 50 days, microangiography and histology of the popliteal lymph nodes were carried out. On the side where BCG was injected, the lymph nodes initially showed a moderately increased cortical, and later, a markedly increased medullary hypervascularity. Histologically, there was mixed mononuclear cellular infiltration followed by granuloma formation. This latter was temporally related to the florid medullary hypervascularity. No significant changes were present on the control side. The hypervascularity induced by BCG was more intense and longer lasting than that seen with other antigens such as Typhoid 0 or bovine serum albumin. The results indicate a prominent vascular component in the BCG-induced primary immune response within the regional lymph node.
先前的研究表明，在免疫反应过程中微血管会发生显著变化。为了评估卡介苗（BCG）诱导的淋巴结微血管改变，我们给23只兔子的左足垫注射了每千克体重1.6×10⁶个活卡介苗；右侧作为对照。在1至50天的时间段后，对腘窝淋巴结进行了微血管造影和组织学检查。在注射卡介苗的一侧，淋巴结最初显示皮质适度充血，随后髓质血管明显增多。组织学上，先是有混合单核细胞浸润，随后形成肉芽肿。后者在时间上与明显的髓质血管增多有关。对照侧未出现明显变化。卡介苗诱导的血管增多比伤寒O抗原或牛血清白蛋白等其他抗原引起的血管增多更强烈且持续时间更长。结果表明，在区域淋巴结内卡介苗诱导的初次免疫反应中存在显著的血管成分。
