Nakamura R M, Easterday B C
Bull World Health Organ. 1967;37(4):559-67.
Reports have been published on the detection of antibodies in animals, including birds, to human influenza viruses. The work reported in this paper was undertaken in an effort to establish an effective method for differentiating specific antibody from non-specific antibody-like substances that occur naturally in serum.The primary antibody response of experimental animals exposed to influenza virus was readily differentiable from the secondary response following challenge of the animals with homologous viral antigen.Field challenge of cattle and sheep resulted in primary responses only, suggesting the non-antibody nature of inhibitor substances present in their sera prior to challenge.Challenge of swine and turkeys that had previously been involved in outbreaks of influenza resulted in secondary responses differentiable from the response of control swine and turkeys similarly challenged.The differentiation of non-specific substances from specific antibody by the challenge method used may help to clarify the role of animals in the epidemiology of human influenza.
关于在包括鸟类在内的动物体内检测针对人流感病毒抗体的报告已有发表。本文所报道的工作旨在努力建立一种有效方法，以区分血清中天然存在的特异性抗体与非特异性抗体样物质。暴露于流感病毒的实验动物的初次抗体反应很容易与用同源病毒抗原攻击动物后的二次反应区分开来。对牛和羊进行现场攻击仅产生初次反应，这表明在攻击前它们血清中存在的抑制物质具有非抗体性质。对先前曾发生流感疫情的猪和火鸡进行攻击，产生的二次反应与同样受到攻击的对照猪和火鸡的反应不同。通过所使用的攻击方法区分非特异性物质与特异性抗体，可能有助于阐明动物在人流感流行病学中的作用。
