Ward Nicholas G, Bloom Valerie L, Friedel Robert O
Department of Psychiatry and Behavioural Sciences, RP-10, University of Washington, Seattle, Wash. 98195, U.S.A. Department of Psychiatry, Medical College of Virginia, Richmond, Va. U.S.A.
Pain. 1979 Dec;7(3):331-341. doi: 10.1016/0304-3959(79)90089-7.
A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin. It was discovered that 100% of these subjects had chronic pain complaints, most of which paralleled the course of depression. Headache was most commonly noted. Doxepin's analgesic effects were intimately associated with its antidepressant effects. There was a highly significant relationship between improvement of depression and reduction of pain on doxepin (P less than 0.005). Conversely, patients who obtained minimal antidepressant effect also obtained minimal analgesic effect. Psychophysiologic and biochemical hypotheses of this association of pain and depression are discussed.
对一组患有中度焦虑的中度至重度抑郁症患者进行了研究，以确定疼痛主诉的频率和性质及其对多塞平的反应。结果发现，这些受试者中有100%患有慢性疼痛主诉，其中大多数与抑郁症病程平行。头痛是最常见的症状。多塞平的镇痛作用与其抗抑郁作用密切相关。多塞平治疗后抑郁症改善与疼痛减轻之间存在高度显著的关系（P<0.005）。相反，抗抑郁效果甚微的患者镇痛效果也甚微。本文讨论了疼痛与抑郁症关联的心理生理和生化假说。
