哺乳期与乳腺癌。一项国际研究综述。
Lactation and cancer of the breast. A summary of an international study.
作者信息
MacMahon B, Lin T M, Lowe C R, Mirra A P, Ravnihar B, Salber E J, Trichopoulos D, Valaoras V G, Yuasa S
出版信息
Bull World Health Organ. 1970;42(2):185-94.
An international collaborative study has been carried out to test the hypothesis that prolonged lactation protects women against cancer of the breast. While pregnancy itself seemed to confer some protection against breast cancer in all areas studied, no consistent differences in duration of lactation were found between breast cancer patients and unaffected women, once the fact that breast cancer patients have fewer pregnancies had been allowed for. Even in areas where some women had lactated for a total of 5 years or more, such women occurred proportionately no less frequently among breast cancer patients than among unaffected women. In the light of this and other recent evidence, it is unlikely that lactation has any protective effect against breast cancer in women, and other explanations must be sought for the remarkable international differences in the frequency of this disease.
一项国际合作研究已经开展，以检验延长哺乳期可保护女性预防乳腺癌这一假设。虽然在所有研究地区，怀孕本身似乎对乳腺癌有一定的预防作用，但一旦考虑到乳腺癌患者怀孕次数较少这一事实，乳腺癌患者与未受影响女性在哺乳期时长方面未发现一致差异。即使在一些女性总哺乳期达5年或更长时间的地区，乳腺癌患者中这类女性的比例与未受影响女性相比也并不更低。鉴于此及其他近期证据，哺乳期不太可能对女性乳腺癌有任何保护作用，对于该疾病发病率存在显著国际差异这一现象，必须寻求其他解释。
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