Ratcliffe H L, Luginbühl H, Pivnik L
Bull World Health Organ. 1970;42(2):225-34.
CORONARY, AORTIC AND INTERCRANIAL ATHEROSCLEROSIS HAS BEEN COMPARED IN SWINE MAINTAINED UNDER THE FOLLOWING CONDITIONS: (1) adequate food and housing but animals held in test social situations for 1 year; postmortem examination at ages of 13 to 15 months; (2) food and management designed for high productivity; postmortem examination at ages of 6 to 9 years; (3) an outdoor system of husbandry and a cooked garbage diet; postmortem examination at ages of 8 to 14 years.Extramural coronary, aortic and intracranial atherosclerosis was most advanced in swine that were fed garbage. Cerebral infarction (cerebromalacia) also was most advanced in these swine but developed in swine of the younger groups in which it was associated with atherosclerosis of small intracranial extracerebral arteries rather than with stenosis of the larger intracranial extracerebral arteries as in the oldest swine. The lesions of atherosclerosis in swine of these 3 age-groups form a continuous series and are morphologically identical with corresponding stages of atherosclerosis of man.It is concluded that swine can replace non-human primates as subjects for studies of atherosclerotic vascular disease, and that experimental designs must allow for age and behaviour patterns of the species.
在以下条件下饲养的猪中，对冠状动脉、主动脉和颅内动脉粥样硬化进行了比较：(1) 食物充足且饲养环境良好，但动物在试验社交环境中饲养1年；13至15个月龄时进行尸检；(2) 为实现高生产力而设计的食物和管理方式；6至9岁时进行尸检；(3) 户外饲养系统和熟食垃圾饮食；8至14岁时进行尸检。在喂食垃圾的猪中，壁外冠状动脉、主动脉和颅内动脉粥样硬化最为严重。脑梗死（脑软化）在这些猪中也最为严重，但在较年轻组的猪中也会出现，在这些猪中，它与颅内脑外小动脉的动脉粥样硬化有关，而不像最老的猪那样与较大的颅内脑外动脉狭窄有关。这三个年龄组猪的动脉粥样硬化病变形成一个连续系列，在形态上与人类动脉粥样硬化的相应阶段相同。结论是，猪可以替代非人灵长类动物作为动脉粥样硬化性血管疾病研究的对象，并且实验设计必须考虑该物种的年龄和行为模式。
