Vázquez F, Téllez C, De La Mora P, Brust-Carmona H
Pharmacol Biochem Behav. 1979 Nov;11(5):499-503. doi: 10.1016/0091-3057(79)90032-7.
Inhibition of movements is the result of the caudate nucleus (CN) activity. This action seems to be necessary for passive avoidance conditioning (PAC). Much data indicates that GABA has inhibitory effects in the CN. The present report provides further evidence for GABA inhibition in th4 CN. In cats, the acquisition session of a PAC response was carried out following the bilateral administration of 6 microgram of picrotoxin or saline in the CN. Twenty four hours later (1st test session) the animals were placed in the security compartment and remained there during 600 sec. In the second test, the cats injected with picrotoxin crossed to the other compartment while the subjects injected with saline did not move. Another series of acute experiments were also carried out. Evoked potentials (EP) were recorded in the CN produced by nucleus centralis medialis electrical stimulation. After picrotoxin application the first and second peaks, which could represent EPSPs, incraeased while the third peak, which could represent IPSPs, decreased. In conclusion, it seems that GABAergic intracaudate transmission maintains a lower level of neuronal discharges and probably participates in the maintenance of a PAC but not in its acquisition.
运动抑制是尾状核（CN）活动的结果。这种作用似乎是被动回避条件反射（PAC）所必需的。大量数据表明γ-氨基丁酸（GABA）在尾状核中具有抑制作用。本报告为尾状核中GABA的抑制作用提供了进一步的证据。在猫中，在双侧向尾状核注射6微克印防己毒素或生理盐水后进行PAC反应的习得训练。24小时后（第一次测试阶段），将动物置于安全隔室中，并在那里停留600秒。在第二次测试中，注射印防己毒素的猫进入了另一个隔室，而注射生理盐水的猫则没有移动。还进行了另一系列急性实验。记录了内侧中央核电刺激在尾状核中产生的诱发电位（EP）。应用印防己毒素后，可能代表兴奋性突触后电位（EPSP）的第一和第二个波峰增加，而可能代表抑制性突触后电位（IPSP）的第三个波峰减小。总之，似乎尾状核内的GABA能传递维持较低水平的神经元放电，并且可能参与PAC的维持，但不参与其习得过程。
