氯贝丁酯对大鼠血浆卵磷脂胆固醇酰基转移酶（LCAT）活性的影响。
Influence of clofibrate on plasma lecithin: cholesterol acyltransferase (LCAT) activity in rats.
作者信息
Cisternas J R
出版信息
Rev Bras Pesqui Med Biol. 1979 Sep;12(4-5):317-24.
Effects of clofibrate on plasma lecithin: cholesterole acyltransferase (LCAT) activity, plasma lipid levels and hepatic cholesterol content were examined in rats with clofibrate treatment for a short period of time. The results show that the administration of the drug for three weeks produces substantial shifts in hepatic cholesterol fractions and induces changes in the plasma LCAT enzyme. It is suggested that clofibrate increases plasma LCAT activity by induction of the enzyme on the microsomal fraction of the hepatic cell and subsequent secretion by the liver. Presumably clofibrate treatment also produces an increase in the rate of hydrolysis of cholesteryl esters in the rat liver.
在短期用氯贝丁酯治疗的大鼠中，研究了氯贝丁酯对血浆卵磷脂：胆固醇酰基转移酶（LCAT）活性、血浆脂质水平和肝脏胆固醇含量的影响。结果表明，给药三周会使肝脏胆固醇组分发生显著变化，并诱导血浆LCAT酶发生改变。提示氯贝丁酯通过诱导肝细胞微粒体部分的该酶并随后由肝脏分泌来增加血浆LCAT活性。推测氯贝丁酯治疗还会使大鼠肝脏中胆固醇酯的水解速率增加。
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