Whiteley A, Signoret J L, Agid Y, Lhermitte F
Rev Neurol (Paris). 1979 Oct;135(8-9):565-72.
Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily. Choline base orally for 3 weeks. Quantitative testing, which evaluate memory capabilities such as learning and recall after delays of 1 hour and 24 hours, were used before and after the administration of Choline. The results of a global statistical analysis did not show any significant difference in the performances obtained before and after choline. However, in two patients, recall performance improvement was confirmed clinically. Most likely, these two patients were suffering from an mild foorm of Alzheimer's disease.
八名患有阿尔茨海默病且有记忆困难但无明显智力衰退的患者，每天口服9克胆碱碱，持续3周。在服用胆碱前后，使用定量测试来评估记忆能力，如1小时和24小时延迟后的学习和回忆能力。整体统计分析结果显示，服用胆碱前后的表现没有显著差异。然而，在两名患者中，临床证实回忆能力有所改善。很可能这两名患者患有轻度阿尔茨海默病。
