Magrath I T, Golding P R, Bagshawe K D
Br Med J. 1971 Jun 12;2(5762):633-7. doi: 10.1136/bmj.2.5762.633.
Choriocarcinoma commonly presents with symptoms resulting from metastases in the lungs, central nervous system, or alimentary tract. This tumour may occur without any gynaecological symptoms and when pelvic examination and uterine curettage show no abnormality. Several years may elapse between the antecedent pregnancy and presentation with metastatic disease. The ability to eradicate these tumours with present chemotherapeutic methods depends on detecting their presence as soon as possible after the antecedent pregnancy.Wider recognition of the varied manifestations of metastatic choriocarcinoma and greater use of tests for chorionic gonadotrophin should result in earlier diagnosis and an improved prognosis in these patients. In particular, such tests should be made in patients with unexplained intracranial haemorrhage, progressive dyspnoea, and gastrointestinal haemorrhage.
绒毛膜癌通常表现为肺部、中枢神经系统或消化道转移所导致的症状。该肿瘤可能在没有任何妇科症状的情况下发生，并且盆腔检查和刮宫术显示无异常。在先前妊娠与出现转移性疾病之间可能会间隔数年。采用目前的化疗方法根除这些肿瘤的能力取决于在先前妊娠后尽快检测到它们的存在。更广泛地认识转移性绒毛膜癌的各种表现并更多地使用绒毛膜促性腺激素检测，应能使这些患者得到更早的诊断并改善预后。特别是，对于有不明原因颅内出血、进行性呼吸困难和胃肠道出血的患者，应进行此类检测。
