石房蛤毒素和河豚毒素对蛙肌运动终板作用的比较。
Comparison of the actions of saxitoxin and tetradotoxin on the motor end-plate of frog muscle.
作者信息
Evans M H
出版信息
Br J Pharmacol. 1971 Nov;43(3):681-3. doi: 10.1111/j.1476-5381.1971.tb07200.x.
End-plate potentials (e.p.p.) and responses to ionophoretic application of acetylcholine (ACh potentials) have been recorded in frog muscle. Saxitoxin (STX) and tetrodotoxin (TTX) abolished the e.p.p. at concentrations of 10(-8) g/ml. In almost all cases there was no effect on the ACh potentials even when the concentrations were raised, STX to 1.2 x 10(-6) g/ml (3.2 x 1O(-6)M), or TTX to 5 x 10(-6) g/ml (1.5 x 10(-5)M). STX, 10(-6) g/ml (2.7 x 10(-6)M) often caused a slow rise in the frequency of miniature e.p.p., without significant effect on amplitude.
已在蛙肌中记录到终板电位（e.p.p.）和对离子电泳施加乙酰胆碱的反应（ACh电位）。石房蛤毒素（STX）和河豚毒素（TTX）在浓度为10⁻⁸g/ml时可消除e.p.p.。在几乎所有情况下，即使浓度提高，STX提高到1.2×10⁻⁶g/ml（3.2×10⁻⁶M），或TTX提高到5×10⁻⁶g/ml（1.5×10⁻⁵M），对ACh电位也没有影响。10⁻⁶g/ml（2.7×10⁻⁶M）的STX常常导致微小e.p.p.频率缓慢上升，而对幅度无显著影响。
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