一种用于治疗血吸虫病的新型锑制剂的实验与临床研究。
Experimental and clinical studies with a new antimonial preparation for the treatment of schistosomiasis.
作者信息
Pedrique M R, Ercoli N
出版信息
Bull World Health Organ. 1971;45(4):411-7.
Abstract
This paper presents the results of a clinical study in which a new antimony preparation-a chelate of dimethylcysteine with antimony sodium tartrate ("NAP")-was administered intramuscularly at a total dosage of 2 g (5x400 mg, corresponding to 290 mg of Sb) to 400 patients with schistosomiasis. Among 108 patients in a rural population the treatment was on the whole well accepted (97% completed the intensive course of injections), thus indicating that NAP would be useful for the mass treatment of schistosomiasis.
摘要
本文介绍了一项临床研究的结果。该研究中，一种新的锑制剂——二甲基半胱氨酸与酒石酸锑钠的螯合物（“NAP”），以2克的总剂量（5×400毫克，相当于290毫克锑）肌肉注射给400名血吸虫病患者。在108名农村患者中，该治疗总体上被广泛接受（97%完成了强化注射疗程），这表明NAP可用于血吸虫病的大规模治疗。
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本文引用的文献
1
Selective antagonism of arsenicals and antimonials.砷剂和锑剂的选择性拮抗作用。
Nature. 1967 Oct 28;216(5113):398-9. doi: 10.1038/216398a0.
2
Clinical experiences with antimonyl-dimethylcysteino-tartrate (NAP) in a rural population infected with Schistosoma mansoni.酒石酸锑钾（NAP）治疗曼氏血吸虫感染农村人群的临床经验。
Ann Trop Med Parasitol. 1970 Jun;64(2):255-61. doi: 10.1080/00034983.1970.11686689.
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[Parameters in the experimental chemotherapy of schistosomiasis 9s. mansoni)].[曼氏血吸虫病实验化疗的参数]
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