Kessel J F
Bull World Health Organ. 1971;44(6):783-94.
District filariasis surveys in Tahiti in the years after the Second World War yielded the highest microfilaria rates in the South Pacific area, ranging from 25% to 44%; the mean elephantiasis rate was 5% and microfilaria densities (MfD(50)) ranged from 18 to 31. A co-operative filariasis research programme was begun and a control programme was inaugurated in 1953, using diethylcarbamazine therapy supported by mosquito larvae control measures. By 1959 fifteen districts had received mass treatment. Re-examination after 12 months showed that the mean microfilaria rate had dropped from 31% to 3% and the MfD(50) from 23 to 4. Subsequently, only positives were re-treated and by 1964 the microfilaria rate had risen to 6.8%. The increase caused concern and the significance of this reservoir of infection was investigated.Administration of diethylcarbamazine in periodic mass treatments only in American Samoa began in 1963 and was accompanied by a drop in the microfilaria rate to less than 1%, leading to interruption of transmission in some areas.
第二次世界大战后的几年里,塔希提岛的地区丝虫病调查得出了南太平洋地区最高的微丝蚴率,范围在25%至44%之间;平均象皮肿率为5%,微丝蚴密度(MfD(50))在18至31之间。1953年启动了一项合作丝虫病研究计划,并开展了一项防治计划,采用乙胺嗪治疗并辅以蚊虫幼虫控制措施。到1959年,15个地区接受了群体治疗。12个月后的复查显示,平均微丝蚴率从31%降至3%,MfD(50)从23降至4。随后,仅对阳性患者进行再治疗,到1964年微丝蚴率升至6.8%。这一增长引发了关注,并对这一感染源的重要性展开了调查。1963年,美属萨摩亚开始仅通过定期群体治疗施用乙胺嗪,同时微丝蚴率降至1%以下,导致一些地区的传播中断。