[Role of bile acids and phospholipids in the stabilization of cholesterol in the gallbladder bile].

A removal of bile acids from the bile by gel-filtration results in a decrease of coagulation threefold of the cholesterol micelle. During enzymatic cleavage of phospholipids in the whole bile, cholesterol is retained in the solution. Under the same treatment of a fraction isolated from the dog bile employing filtration through Sephadex G-75 and devoid of bile acids, cholesterol completely precipitated. The data obtained indicate an important role of fatty acids in the stabilization of cholesterol in the bile, phospholipids play a less role in this process.